On June 28, 2017, the Los Angeles Clippers acquired Williams, Patrick Beverley, Sam Dekker, Montrezl Harrell, Darrun Hilliard, DeAndre Liggins, Kyle Wiltjer, and a 2018 first-round pick from the Houston Rockets in exchange for Chris Paul. On November 27, 2017, Williams scored a season-high 42 points in a 120–115 win over the Los Angeles Lakers. On December 9, 2017, he hit a go-ahead pull-up 3-pointer with 1.2 seconds remaining, lifting the Clippers to a 113–112 victory over the Washington Wizards. He finished with 35 points to lead a dominant bench effort for the Clippers. On December 31, 2017, he scored 40 points off the bench in a 106–98 win over the Charlotte Hornets. Williams was subsequently named Western Conference Player of the Week for games played Monday, December 25 through Sunday, December 31. On January 10, 2018, he scored 27 of his career-high 50 points in the third quarter of the Clippers' 125–106 win over the Golden State Warriors. He shot 16 for 27 with a career-best eight 3-pointers and made all 10 of his free throws. It was the highest scoring effort by any Clipper in a single game since Charles Smith tied a franchise record with 52 points in December 1990. Williams was subsequently named Western Conference Player of the Week for games played Monday, January 8 through Sunday, January 14. On January 20, 2018, he recorded 31 points, a franchise-record 10 steals, and seven assists in a 125–113 loss to the Utah Jazz. He became the first player in league history to reach 30 points, 10 steals, and seven assists in a game since steals became a recorded stat. On January 26, 2018, he had 40 points and matched his season high with 10 assists in the Clippers' 109–100 victory over the Memphis Grizzlies. On February 7, 2018, he signed a multi-year contract extension with the Clippers. On February 23, 2018, he had 35 points in 33 minutes, including a 23-point second quarter, in a 128–117 win over the Phoenix Suns. Williams averaged career highs in points (22.6), assists (5.3), and minutes (32.8) during the 2017–18 season. His bench scoring led the NBA in his 13th season. He was subsequently named NBA Sixth Man of the Year for the second time in his career.